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Embryology (Fresh embryos) section 

This section is applicable to:

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This section collects this information from the (blue star) Laboratory details folder.

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Field

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97.

Insemination method
Methodology used to inseminate the oocytes
Select all applicable in particular when inseminations were done on more than one day such as for IVM cycles where ICSI is done on various days depending on the oocyte maturity (see embryo 10+11).

Mandatory if 82. Number Oocytes Retrieved or Thawed (ART0410) > 0.
ICSI on day 2' and 'ICSI on day 3' are only selectable for IVM cycles
The value 'Not done' is mutually exclusive

For cases where all oocytes are immature or no sperm are available, select 'Not done'

If insemination method was IMSI, select 'ICSI'

IVF using vaginal incubator device INSM011
Conventional IVF on day 0 INSM001
IVF on day 0 with rescue ICSI on day 1 INSM002
ICSI on day 0 INSM003
ICSI on day 1 INSM004
ICSI on day 2 - IVM only INSM005
ICSI on day 3 - IVM only INSM006
Not done INSM007

98.

# oocytes inseminated/injected
Number of COCs inseminated by conventional IVF and/or number of oocytes injected by ICSI (see embryo 1/11).

Mandatory if 82. Number Oocytes Retrieved or Thawed (ART0410) > 0
Must be <= 82. Number Oocytes Retrieved or Thawed (ART0410)

99.

# oocytes not used
Number of COCs collected in a fresh cycle or number of thawed/warmed oocytes that were not used in this cycle. (embryo 12)

Mandatory if 82. # of Oocytes Retrieved (ART410) > 0
Must be = 82. # of Oocytes Retrieved (ART410) - # 98. oocytes inseminated/injected (ART0530) - 104. # of oocytes cryopreserved (ART0420)

100.

Reasons for no use
Reasons for not using some of the COCs or thawed/warmed oocytes.

Mandatory if 99. # oocytes not used (ART0540) > 0

Immaturity NOUSE001
Degeneration NOUSE002
Religious belief NOUSE003
No sperm NOUSE004
Inadequate number of sperm NOUSE005
Donated to another patient NOUSE007
Donated to research NOUSE008
Abnormal NOUSE009
Information not available NOUSE006

This fields needs to be filled in manually.

101.

# of MII oocytes
Number of MII oocytes injected and/or number of MII oocytes on day 1 after conventional IVF (not possible to have an accurate value on day 0 in conventional IVF) (see embryo 1/10).

Mandatory if 98. # oocytes inseminated/injected (ART0530) > 0
Must be <= 82. Number Oocytes Retrieved or Thawed (ART0410)

102.

Normal fertilization(2PN)
Number of zygotes with normal fertilization, i.e. 2PN  (See embryo 2/8)

Mandatory if 98. # oocytes inseminated/injected (ART0530) > 0
Must be <= 98. # oocytes inseminated/injected (ART0530)

103.

# utilizable  embryos
Number of embryos transferred and frozen
If no consent for freezing, include embryos suitable for freezing at the end of the culture period (Embryo 2/5 and 7/9).

Mandatory if 98. # oocytes inseminated/injected (ART0530) > 0
Must be <= 98. # oocytes inseminated/injected (ART0530)

Embryology (Freeze) section

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Field

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104.

# embryos cryopreseved
Number of embryos frozen or vitrified in an IVF cycle.

These are the embryos which fate are  “Freeze embryos” (See embryo 4,5,7,8 and 9).

Mandatory if 98. # oocytes inseminated/injected (ART0530) > 0.
If none, set to '0'
If 16.Type of cycle (ART0160) = 'IVF', 'IVM', or 'Frozen Oocytes', then must be <= 103. # utilizable embryos (ART0580) if 16.Type of cycle (ART0160) = 'IVF', 'IVM', or 'Frozen Oocytes'
If 16.Type of cycle (ART0160) = 'FET', then must be <= 122. # embryos thawed (ART0670)
Applicable in an FET cycle if embryos thawed but then refrozen before use

105

Reason for cryopreservation

Later own use CRY001
Later donation CRY002
PGT-A testing CRY003
PGT-M/PGT-SR testing CRY004
Other CRY005

Later own use will be selected when embryos are frozen and there is an embryo transfer.
Later donation will be selected when embryos are stored for research (lab event).
When using laborders and 'Reason for freeze all' has been filled in, the optioncode of the selected item will be added to this list.

106.

Embryo stage at freezing
The stages of the embryos will be ticked of the frozen embryos (See embryo 7/9).

Pronuclear stage (2PN) ESTG001
Cleavage stage ESTG002
Morula ESTG003
Blastocyst ESTG004
Unknown UN

107.

Embryo cryo method
Method used to cryopreserve the embryos  This is filled in the Freeze event.

Vitrification ECRY002
Slow freezing ECRY001
Mixed ECRY003

108-110-112-114.

Embryo freeze ID # 1-2-3-4
Unique code to identify freeze of a batch of embryos from this cycle.
This is an internal number created by IDEAS.

109-111-113-115.

Embryo Freeze date # 1-2-3-4
This is the date the embryos are frozen in a previous cycle.
This is filled in the  Laboratory details folder of that cycle.

Artificial Intelligence section

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Field

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212

Type of incubator used to keep embryo(s) in a controlled environment outside the human body
Type of incubator used to keep embryo(s) in a controlled environment outside the human body

Mandatory if 103. # utilizable embryos (ART0580) > 0

Benchtop incubator (MINC+, MIRI Benchtop, G210, G185, Planer BT37 etc.) EIT001
Box incubator (Heracell, Panasonic, Sanyo etc.) EIT002
Time-lapse incubator (Embryoscope, Geri, MIRI TL etc.) EIT003
Other OTHER
Unknown UN

213

Artificial Intelligence (AI) tool used in embryo assessment or selection?

Use of gamete/embryo image analysis-based data by an Artificial Intelligence system, either integrated or external to the incubator, to generate a score or scale that aids embryologists in the decision-making process for selecting embryos suitable for transfer. The selection may apply to select embryos for vitrification or biopsy but ultimately will be used to ‘order’ the embryos for transfer

Mandatory if 103. # utilizable embryos (ART0580) > 0

214

Artificial Intelligence (AI) score source (tool) type

Type of Artificial Intelligence (AI) tool used in embryo assessment or selection

Mandatory if 103. # utilizable embryos (ART0580) > 0

AIVF (EMA) ATT001
Embryionics ATT002
Fairtility (CHLOE) ATT003
IVF2.0 ATT004
Life Whisperer ATT005
Time-lapse (TL) Integrated (IDAscore, KIDscore etc.) ATT006
Other OTHER
Unknown UN

215

Other Artificial Intelligence (AI) tool

Enabled and optional if 214. Artificial Intelligence (AI) tool type (ART4499) = 'Other'

Embryology (Frozen Embryos) section

This section is mainly for FET cycles.
Occasionally, embryos may be thawed in a fresh cycle (eg, if no or only poor quality fresh embryos are available for transfer).
In this situation, you should enter the data here.
If embryos were thawed, all fields are required, except 115. / 117. Freeze ID of thawed embryos boxes.
If the thawed embryos were from more than one batch, use the additional Freeze ID boxes.
If no embryo was thawed in a planned FET cycle, the cycle should not be entered to CARTR+ at all.
If no embryo was thawed in a fresh cycle, just leave this section blank.

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Field

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116.

Embryo thaw date
Date of embryo thawing/warming with the intent of transferring them in an FET cycle

117.

Freeze ID # 1-4 of thawed embryos
Unique code originally assigned to the embryo cohort at freezing.
For frozen embryos received from another clinic, code given by receiving clinic for that cohort of embryos.

This is an internal number created by IDEAS.

118.

119.

120.

121.

Donated Embryo from another couple
If the embryo is donated by another couple it will say “Yes”

122.

# embryos thawed
Number of embryos that are thawed in a “Thawed” event.

123.

Thawed Embryo stage at freezing
Type of embryos thawed/warmed in this FET cycle

Pronuclear stage (2PN) ESTG001
Cleavage stage ESTG002
Morula ESTG003
Blastocyst ESTG004
Unknown UN

124.

Thawed embryo cryo method
Type of method used to cryopreserve the thawed/warmed embryos

Slow freezing    ECRY001
Vitrification    ECRY002
Mixed             ECRY003

125.

# utilizable embryos after thaw
Number of thawed/warmed embryos utilizable for transfer by end of culture post thaw/warm