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CARTR 2025 - Stimulation

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CARTR 2025 - Stimulation

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General remarks

 

 

The Patient information tab has 3 sections:

 

 

Ovarian reserve section

Only 44. Age of oocyte provider is mandotory in this section.
In this section IDEAS will gather the information of the ovum/oocyte donor (This can be the patient).

 

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45.

Age of oocyte provider
Patient age at oocyte collection when using own oocytes or donor age at oocyte collection when using donor oocytes.

When Oocyte Origin (ART0370) is populated with Fresh own oocytes (OORG001) or Frozen own oocytes (ORG002), 'Age of oocyte provider' will be calculated using ART date of birth (ART0030) and Oocyte collection date (ART0340). The calculated age will be automatically populated in the 'Age of oocyte provider'.
Range: 10 - 65.

78. OocyteOrigin (ART0370) or 135. SourceTransferredEmbryos (ART0810) indicates donor oocytes, then should be less than or equal to 35

 

46.

Height of the oocyte provider
Height of female patient at beginning of cycle when using her own oocytes; height of oocyte donor when using donor oocytes. 

Must be reported in cm
Must be between 90 cm and 240 cm
If unknown, set to '0'

These items can be found in the Physical Characteristics tab of the oocyte provider.

 

47.

Weight of the oocyte provider
Weight of female patient at beginning of cycle when using her own oocytes; weight of oocyte donor when using donor oocytes.

Must be reported in kg
Must be between 25 kg and 227 kg
If unknown, set to '0'

48.

BMI of the oocyte provider
BMI of female patient at beginning of cycle when using her own oocytes.

If Height and Weight are provided, the system will calculate and ignore any value in this field
If Height and Weight are not provided, the system will take the value from this field

49.

AFC of oocyte provider
Antral Follicle Count of menstrual cycle of oocyte provider.

If unknown, set to '0'

This can be filled in the Baseline event in the Ultrasound section.

  1.  

AFC date
Date Antral Follicle Count was taken (closest to cycle start date)

If unknown, set to '19000101'

 

50.

AMH level of oocyte providerAnti-Mullerian Hormone level of oocyte provider.
Value to be provided in ng/mL.

This is filled in the Blood / lab tests folder.

  1.  

AMH level date
Date Anti-Mullerian Hormone level of oocyte provider was taken (closest to cycle start date)

If unknown, set to '19000101'

 

51.

51. Cycle stopped
Indicates if a cycle was stopped before stimulation started in IVF/IVM/oocyte banking cycles or before oocytes or embryos thawed in Frozen oocyte IVF/FET cycles.

Stopped cycles are not required in CARTR Plus.
If 'Yes', the record will be filtered and not loaded into CARTR Plus

This will be "Yes" when the cancellation date is before Day 1.

Stimulation protocol - Oocyte provider

In this section, 52.Type of Stimulation Protocol, 56. Medication for COS, and 60. Trigger Medication are required.
If “Other” is selected for any of the four protocol/medication fields, you may type in a description of that other protocol/medication in the box to the right.
If 56. Medication for COS includes a gonadotropin (hMG or FSH), you need to fill in 62.No. of days of Gonadotropins and 64. Total Dose of FSH.

 

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52.

Type of stimulation protocol
Ovarian stimulation protocol received by oocyte provider.
In a donor oocyte cycle, the protocol is the one received by the donor and not recipient.

If 62. Number of days of gonadotropins is (ART0250) > 5 days, cycle should not be classified as modified natural. Consider selecting another stimulation protocol type.

 

Antagonist SPT004
Long agonist SPT006
Flare agonist SPT007
Natural cycle SPT001
IVM protocol SPT009

This needs be filled in Performed treatment or otherwise on the Intended treatment tab.

53.

Other type of stimulation

Only applicable if 51.Type of stimulation protocol (ART0210) = 'Other'

 

54.

Medication prior to COS

Mandatory field (except FOIVF and FET cycles)
'None' is mutually exclusive

None MPC001
Estrogen oral, vaginal or patch (Estrace, Climare, Estradot, etc.) MPC002
Oral contraceptive (Alesse, Marvelon, etc.) MPC003
GnRH agonist (Lupron, Suprefact) for 3 or fewer days) MPC004
GnRH agonist (Lupron, Suprefact, Zoladex) for more that 3 days MPC005
GnRH antagonist (Orgalutran, Cetrotide) MPC006
Progesterone (Provera) MPC007
Other MPC008

 

55.

Other medication prior to COS

Only applicable if 54. Medication prior to COS (ART4492) = 'Other'

 

56.

Medication for COS
Medication received for controlled ovarian stimulation (COS)
In a donor oocyte cycle, the medication is the one received by the donor and not recipient

'None' is mutually exclusive

Oral | Letrozole COSM014
Oral | Clomiphene citrate COSM001
Oral | Tamoxifen COSM015
Injectable | Follicle stimulating hormone (FSH) (Puregon, Gonal-F, Rekovelle) COSM016
Injectable | Leutinizing hormone (LH) (Bravelle, Luveris) COSM017
Injectable | FSH+LH (Menopur, Repronex) COSM018
LH suppression | Cetrorelix (Cetrotide) COSM019
LH suppression | Orgalutron (Ganirelix) COSM020
LH suppression | None NONE
LH suppression | Other OTHER

 

57.

Other medication for COS
If an “Other” drug is used in the treatment, the drug will be filled in here.

Only applicable if 56. Other medication for COS = 'Other'

 

58.

Adjuvant medication
Medication received to modify the effect of the gonadotropins
In a donor oocyte cycle, the medication is the one received by the donor and not recipient.

Optional field

None NONE
Aspirin (ASA) ADJ008
Steroid (dexamethasone, prednisone, decadron) ADJ004
Thyroid medication (topical, patch) ADJ006
Dopamine Receptor Agonist (cabergoline, dostinex, cabaser) ADJ010
CoQ10 ADJ003
Growth Hormone ADJ001
Testosterone patch ADJ007
DHEA ADJ002
Metformin ADJ009
Sildenafil ADJ005
Other OTHER

 

59.

Other Adjuvant medication description
If an “Other” drug is used in the treatment, the drug will be filled in here.

Only applicable if 58. Adjuvant medication = 'Other'

 

60.

Trigger medication

Medication received to complete oocyte maturation before collection.
The name of the trigger used will be filled in here.

hCG TGM006
GnRH agonist TGM003
hCG + GnRH agonist TGM007
Other OTHER

If 71. Cycle canceled (ART0320) = 'Yes', then Optional

 

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61.

Other trigger medication

Only applicable if 60. Trigger medication (ART0240) = 'Other'

 

62.

No. of days of gonadotrophins
Number of days of stimulation from 1st day of FSH to trigger day or day of cancellation. This can be seen in the Cycle summary of the patient or the Edit treatment dialog.

Mandatory if 56. Medications for COS (ART0220) contains

  • Follicle stimulating hormone (FSH) (Puregon, Gonal-F, Rekovelle)',

  • Leutinizing hormone (LH) (Bravelle, Luveris)'

  • FSH+LH (Menopur, Repronex)'

Range 1 - 45

63.

Total dose of FSH
Total IU of FSH received in cycle – does not include dose of LH.
(If converting from mcg use a conversion rate of 1 mcg = 0.002 IU)
This is the dose of confirmed FSH medication.

Total dose of FSH (ART0260) or 64. Total dose of FSH Rekovelle in mcg (ART0260R) are required if 62.Medications for COS (ART0220) contains

  • Follicle stimulating hormone (FSH) (Puregon, Gonal-F, Rekovelle)

  • Leutinizing hormone (LH) (Bravelle, Luveris

  • FSH+LH (Menopur, Repronex)
    Range: 50 - 30000

 

64.

Total dose of FSH Rekovelle
Total mcg dose of Rekovelle FSH received in cycle – does not include dose of LH.

Total dose of FSH (ART0260) or 64. Total dose of FSH Rekovelle in mcg (ART0260R) are required if 62.Medications for COS (ART0220) contains

  • Follicle stimulating hormone (FSH) (Puregon, Gonal-F, Rekovelle)

 

65.

Total dose of LH in IU

Optional field

UI Warning: value should not exceed 5000IU

 

Ovarian response - oocyte provider section

In this section, only 66 # Follicles  >= 15 mm and 71. Cycle Cancelled are required.
If an oocyte donor or gestational carrier is used, do not fill in the 70. Endometrial Thickness here – there will be a box for the Endometrial Thickness of the embryo recipient on the Embryo & Transfer tab.
If you tick “yes” for 68. Cycle Cancelled, you must select an option for 72. Reason Cancelled; if you select “other”, you may fill in a description in 73. Other reason cancelled description.

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66.

.# of follicles <15mm

Number of small growing follicles (<15mm) at trigger or cancellation. Number of large growing follicles (≥15 mm) at trigger or cancellation. 
These two can be seen in the  Ultrasound section of the patient.

The cut off line needs to be filled in System / options.

UI warning: value exceeds 50, please confirm
This is a mandatory field but, based on feedback, there may be a specific scenario where it cannot be provided.
If the field is not populated, a warning message will be displayed in CARTR Plus.
The warning will not prevent the record from being submitted.

The numbers that are shown here are rounded, it is possible that it does not add up with the Scan details.
Check the follicle tracking sheet.

67.

.# of follicles >15mm

This is a mandatory field

If unknown, set to '0'

 

68.

Estradiol level
Serum Estradiol value (in pmol/L) within one day of trigger or cancellation.

This the latest entry in the Blood / Labtests section.

Optional field

69.

Progreserone level
Serum Progesterone value (in nmol/L) within one day of trigger or cancellation.

This the latest entry in the Blood / Labtests section.

Optional field

 

70.

Endometrial thickness Fresh cycle
Thickness (mm) of endometrium within a few days of trigger or cancellation.If an oocyte donor or gestational carrier is used, do not fill it in here.
This can to be filled in 125. Endometrial thickness Frozen on the Embryology & Transfer tab.
IDEAS collects this information from the last tracking scan in the   Ultrasound folder of the patient.

Applies to person who will be receiving embryo.
Does not apply for cycles using donor oocytes or when “freeze-all cycle” is intended.

Optional field

71.

Cycle cancelled
ART cycle in which ovarian stimulation or monitoring has been carried out with the intention to treat, but did not proceed to follicular aspiration.

If 16. Type of cycle (ART0160) = 'FET' or 'FOIVF', then cannot equal 'Yes'
If 126. Embryo Transfer (ART0710) = 'Yes' or # of 134. Embryos Transferred (ART0790) > 0, then cannot equal 'Yes'
If 82. Number of oocytes retrieved (ART0410) > 0 or 22. Oocyte collection date (ART0340) is populated, then cannot equal 'Yes'
If 72. Reason Cancelled (ART0330) is provided, then must equal 'Yes

If oocytes or embryos are not thawed, cycle can be included in CARTR Plus but it should be set as a 51. Cycle stopped (ART0205) = 'Yes'. It should not be considered a "cancelled" cycle.

Upload will automatically set 147. Treatment Outcome (ART0860) to 'cycle not completed to transfer' and
148. Type of Pregnancy (ART0870) to 'not pregnant' if Cycle Canceled (ART0320) = 'Yes'.

Pregnancies related to cancelled IVF cycles converted to IUI are not tracked in CARTR Plus.

This needs to be filled in the Treatment plan tab of the Treatment cycles.

72.

Reason cancelled
This field is only applicable when 71. Cycle cancelled is "Yes".
Fill in the reason of cancellation (this can be more than one):

Patient illness CNC001
Patient personal reason CNC002
Medication error CNC012
Low ovarian response CNC004
High ovarian response CNC005
Premature ovulation CNC006
Premature luteinization CNC007
Donor issue CNC013
Other OTHER

73.

Other reason cancelled description
Description of reason for cancellation of oocyte collection if set to "Other"

Oocyte collection section

In this section, 74. Oocyte collection date, 78. Oocyte Origin, and 82. # Oocytes Retrieved / Thawed are required.
In an IVF or IVM cycle, the three fields for entering information about thawed oocytes are to be used in the rare situation that a fresh oocyte retrieval is attempted with no or insufficient oocytes retrieved, so some frozen oocytes are thawed.
If 78. Oocyte Origin includes donor oocytes, fill in information about the donor in the next two boxes (79. Oocyte Donor Status is required).
If any oocytes are cryopreserved, Oocyte freeze ID, date and method need to be filled in.

 

 

 

 

 

 

74.

Oocyte collection date

Date of Oocyte collection should be < 60 days after 20. CycleStart Date.

This needs to be filled in the Egg collection event of the Laboratory details

75.

Oocyte thaw date
Date of oocyte thawing/warming.

Mandatory field for FOIVF cycles. For IVF, IVM or OB cycles it’s optional.
For FET cycles it needs to be blank

 

76.

Freeze ID # 1 of thawed oocytes
Unique code originally assigned to the oocyte cohort at freezing.

Optional field

 

77.

Freeze ID # 2 of thawed oocytes

For frozen oocytes received from another clinic, code given by the receiving clinic to that cohort of oocytes.

Optional field

This is an internal number created by IDEAS.

 

78.

Oocyte origin
Origin of oocytes used to create embryos or for banking.
Choose partner oocytes when same-sex female partner provides oocytes for same-sex partner to be the embryo recipient.

Mandatory field
This is actual oocyte origin used and not intended origin

Fresh own oocytes OORG001
Frozen own oocytes OORG002
Fresh partner oocytes OORG005
Frozen partner oocytes OORG006
Fresh donor oocytes OORG003
Frozen donor oocytes OORG004

 

79.

Oocyte donor ID
Unique code to identify the oocyte donor.

Only applicable if Oocyte Origin (ART0370) =

  • Fresh donor oocytes (OORG003) or

  • Frozen donor oocytes (OORG004)

 

80.

Oocyte provider source
Unique name of commercial oocyte bank for oocytes sourced from commercial egg bank or chart number of donor patient (if donated at same clinic).

Optional field

This needs to be filled in manually.

81.

Donor / provider status
Type of donation.For same-sex female partner oocyte provider, choose non-anonymous.
If oocyte provider intends to keep some oocytes for own use, choose non-anonymous or anonymous oocyte sharing, whichever applies.

Only applicable if Oocyte Origin (ART0370) =

  • Fresh donor oocytes (OORG003) or

  • Frozen donor oocytes (OORG004)

Anonymous ODON001
Anonymous oocyte sharing ODON003
Directed oocyte sharing ODON004
Anonymous from commercial oocyte bank ODON005

When a donor is used the status of the donor will be filled in automatically.

 

82.

Number oocytes retrieved
Number of cumulus-oocyte complexes (COCs) collected and/or number of oocytes thawed.

Mandatory field

Range: 0 - 200
UI Warning: Value should be between 0 and 55

This needs to be filled in the Egg collection event.

 

83.

# oocytes cryo preserved
Number of oocytes frozen or vitrified in an oocyte banking cycle or an IVF cycle e.g. no sperm or very few sperm were available.

Mandatory if 82. Number Oocytes Retrieved or Thawed (ART0410) > 0

If none, set to 0

84.

Oocyte freeze ID
Unique code to identify that cohort of frozen oocytes.

Only applicable if 83. # of oocytes cryopreserved (ART0420) > 0

 

85.

Oocyte freeze date
Date of oocyte cryopreservation.

Mandatory if 83. # of oocytes cryopreserved (ART0420) > 0

 

86.

Oocyte cryo method
Type of method used to cryopreserve the oocytes.

Slow freezing
Vitrification
Mixed

Mandatory if 83. # of oocytes cryopreserved (ART0420) > 0

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